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Several clinical trials were held to verify the effectiveness of AC NET in fighting and preventing acne. Please find this data below.
We also have some further information regarding the development stages of acne, which you can access by clicking here. |
AC Net contains oleanolic acid, which inhibits 5-A reductase to fight hyper seborrhea, while the NDGA contained is a cell growth regulator that inhibits hyperkeratosis (excessive build-up of skin cells on the surface of the skin) and inflammation. The AC NET is formulated in an osmotic gel, which also helps to control bacterial growth.
Olive leaf extract is also included in this compound and has superb anti-inflammatory as well as antimicrobial properties, containing oleuropein, 11-demethyl oleuropein , 7,11-dimethyl ester of oleoside, ligustroside, oleuroside and unconjugated secoiridoid.
It also contains triterpenes and flavonoids such as rutin, apigenin and luteolin glycosides. Although we do not use olive leaf extract on its own, the active ingredient found in olive leaf makes out part of the AC.NET active ingredient in our Problem Skin Range.
From the table below, it can be seen that a 72% reduction was achieved, when the active ingredient was used at a 3% inclusion - as is used in our products.
When using the AC NET at a 3% inclusion rate, a 100% level of inactivation is achieved for the Propionibacterium acnes, as well as Acinetobacter calcoaceticus bacteria and Pityrosporum ovale yeast.
These bacteria and yeast are involved in the development of acne, and for this reason the complete inactivation of the bacteria and the yeast is of prime importance when fighting acne.
At a 3% inclusion of AC NET in our products, a reduction of excess sebum (skin oil) of 54.1% was achieved - this result was achieved by means of 5a-reductase inhibition.
The amount of sebum (skin oil) secreted was verified, before the volunteers, with oily or combination skins, started the trial.
The volunteers then applied a cream containing 3% AC NET, twice a day over a six week period, and readings were then taken again and tabulated as above.
During the same testing phase, the amount of active glands were also checked and the results are as follows.
Since the number of active oil glands also play a role in acne, these were also measured during the clinical trials.
Skin cells shed normally, but with hyperkeratinization (hyperkeratinisation) this process is interrupted and the skin cells do not shed, which then causes the sebaceous (oil) duct leading to the surface of the skin to clog.
The graph below shows the dermatological evaluation of the results obtained when volunteers applied a gel containing the active, twice daily, for a period of 8 weeks.
The graph below shows the evaluation by the test volunteers on acne lesions.
Underneath, a typical before and after photo of a test subject that used the gel twice daily as prescribed.
This ingredient is manufactured by the French firm Sederma, which also holds the patent (FR 2 830 195 - PCT/FR 02/03344) for this particular application. AC.NET™ is an association of oleanolic acid and nordihydroguaiaretic acid (NDGA) in an osmotic gel, and is used in our Problem Skin Range.
The INCI names attributed to AC.NET are Butylene Glycol / PEG-60 Almond Glycerides / Caprylyl Glycol / Glycerin / Carbomer / Nordihydroguaiaretic Acid / Oleanolic Acid.
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