Serilesine^® - increase in skin elasticity 

Different clinical tests were done to prove that Serilesine helps to keep skin aging at bay by stimulating various mechanisms.

This page looks at how it increases skin elasticity.

To place this in context with how it helps to fight aging and to have a younger looking skin, please look at the Serilesine summary page by clicking here.

In vivo evaluation of skin appearance

SERILESINE® has been tested in vivo on a group of 20 female volunteers, aged 18 to 70. A cream containing 0.005% SERILESINE® was applied twice a day during 60 days on the hip and thigh area. Several parameters were measured instrumentally or visually and physically evaluated by a dermatologist.

Skin elasticity

The elasticity measurements are performed with a Cutometer®. For this test, a suction cycle of 1 second at 500 mBar followed by a release cycle of one second was selected.

In elastometric measurement, the skin surface is aspirated from the depression induced by the machine into the aperture of the elastometer’s measuring probe. The depth of the skin penetration inside the probe is measured by an optic sensor. Cutaneous elasticity reflects the skin’s potential capacity (measured in mm) for retraction.

A graph is obtained that represents the deformation curve of skin undergoing aspiration, and includes two components.

• An elastic component (Ue), which corresponds to the part of the curve that rises rapidly, and is reversible to the deformation;
• A plastic component (Uv), which corresponds to the part of the curve that rises slowly and is not completely reversible to the deformation.

The total distension of the skin obtained at the end of an aspiration cycle is defined as skin extensibility (Uf).

During the releasing phase, the quantity of deformation remaining in the skin can be observed (Ua=residual deformation). Cutaneous elasticity is defined as the ratio:

Elasticity = Uf-Ua/Uf

It represents the recovery degree of the maximum deformation reached, whose values range between 0 and 1 (maximum elasticity).

Skin elasticity, as measured with a Cutometer significantly increased after 60 days

Due to the fact that combining all the images on one page makes it too large to download within a fair period of time, we created different pages dealing with each aspect that was tested.

The other test that were performed can be viewed by clicking the hyperlink.

• Serilesine increases Laminin (I)
• Serilesine increases Laminin (II)
• Serilesine increases a6-Integrin production
• Serilesine stimulates hemidesmosome formation
• Serilesine increases keratinocyte bonding
• Serilesine increases keratinocyte creation
• Serilesine increase the creation of fibroblast
• Serilesine increases skin elasticity
• Serilesine increases skin compactness (firmness)
• Serilesine increases skin tone
• Serilesine increases skin smoothness

If you are looking for the summary page of Serilesine please click here.