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In skin aging, one aspect that is often overlooked is the “Derma Epidermal Junction” – DEJ – and is the layer in the skin, which supports the epidermis and also acts as the “communication” layer between the top epidermis and the lower dermis.
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Although this page is a bit technical, we have tried to keep it as straight forward since we feel that many people, interested in preventing and retarding aging, would be interested in this. |
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Serilesine is used in the following products: |
On this page
The DEJ is physically a basement membrane and separates the epidermis and the extracellular matrix (ECM), which lies below it in the dermis.
This membrane is composed of two layers – the basal lamina and the underlying reticular lamina.
The basal lamina is rich
in collagen type IV, proteoglycans, as well as the glycoproteins – entactin and laminin. These molecules provide both structure as well as attachment (bioadhesive) qualities.
While the collagen performs a structural role in the skin, the laminin is involved in the functioning and activation of the cells – and is involved in processes of cell creation, passage through the skin as well as adhesion. These processes are essential
for the skin to maintain proper functioning.
Laminin is only found in the basement membranes and is made up of three very long polypeptide chains (alpha, beta and gamma) and held together with disulfide bonds.
Keratinocytes, also called squamous cells, are the primary cell types found in the epidermis; the outer layer of skin, and these cells recognizes the binding properties of laminin - particularly laminin-5. They use their own integrin receptors and trans-membrane proteins located at specific junction points called hemidesmosomes.
From the age of 30, the bond between epidermal cells and the basement membrane starts to decrease, and this loss of contact leads to the functional and structural changes normally associated with aging skin.
During the aging process, certain features of the DEJ are altered and the keratinocytes lose their grip and while this is happening, even less laminin is made in the skin, further adding insult to injury and leading to a loss of contact between the dermis (the bottom layer of the skin) and the epidermis (the outer layer of the skin).
This leads to the skin losing elasticity and becoming saggy and tired looking – as proper contact must be maintained between the dermis and epidermis to ensure proper transport of oxygen, nutrients as well as proper waste removal from the cells.
What Serilesine® does is that it stimulates and restores the skin’s normal functioning by promoting production of laminin as well as the creation of both keratinocytes and fibroblast, which in turn leads to a far more elastic skin that is more compact
(firm) with better tone and improved skin smoothness.
It therefore fights the deterioration of the derma-epidermal connection caused by aging and replenishes this layer of the skin by boosting the manufacture of laminin-5 and increasing the formation of keratinocytes as well as fibroblast, leading to restructuring of the skin and a resultant younger looking complexion.
To clinically ascertain that Serilesine works, various clinical studies were undertaken and these can be viewed by clicking the links below.
The clinical studies are listed on individual pages to reduce the download time of the images.
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