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On this page we look at how topically applied Vitamin A stimulates cell division of human keratinocytes in the skin. The tests were done on human skin, and
show that vitamin A plays a role in stimulating cell division of human keratinocytes.
- Cells were exposed daily for 30 minutes to a culture fluid with 1 ug/ml Vitamin A alcohol. REF 89
Epithelial outgrowths (keratinocytes) from normal human skin in vitro were exposed daily for 30 min to vitamin A alcohol for periods up to 5 weeks.
There was a markedly decreased number of keratohyaline granules in treated cultures, indicating an effect on the differentiation process, but there was no evidence for mucous metaplasia.
The area of vitamin A-treated outgrowths was greater than that of controls at all times. In addition, there was a higher mitotic index, higher labeling index, and larger growth fraction in treated cultures.
The combination of altered differentiation and enhanced proliferation of keratinocytes would appear to account for the larger outgrowth area found in
vitamin A-treated cultures.
Vitamin A in our skin care products 
We use vitamin A in a selection of our skin care products.
For more information on vitamin A and the products in which it is used, please click here.
To view our complete selection of products, please click here.
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PLEASE NOTE:
Although we quote some animal studies, we at Dermaxime do NOT test any of our products on animals.
For more on animal testing and our stand on this, please click here. |
More Vitamin A information pages
Other ingredient information pages
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